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Partnership

Public partners


CNR   CNR


Italy

Scientist-in-charge:
Dr. Michele Muccini

CONSIGLIO NAZIONALE DELLE RICERCHE
Istituto per lo Studio dei Materiali Nanostrutturati di Bologna

At CNR-ISMN cell viability and adhesion studies on organic material interfaces will be performed to assess the response of in vitro primary cell cultures (PNS neurons and glial cells). Materials will be provided by UPV- EHU as well as by ETC and EMSE. 

CMBN   CMBN


Norway

Scientist-in-charge:
Dr M.Amiry-Moghaddam

CENTRE FOR MOLECULAR BIOLOGY AND NEUROSCIENCE
Dept of Anatomy
Lab for Molecular Neuroscience

CMBN will study at a molecular level, by in vitro and in vivo immunogold EM (IEM), the effect of interfacing organic devices with neural ultra-structures (i.e extracellular matrix protein, ion- and water-channel membrane expression, protein markers of gliotic state) from CNS. 

 ENSMSE   EMSE


France

Scientist-in-charge:
Prof. George Malliaras

ECOLE NATIONALE SUPERIEURE DES MINES DE SAINT ETIENNE
Departement of Bioelectronics – Centre Microélectronique de Provence

EMSE will develop organic electrochemical cells transistors OECT to elicit, modulate and record neural cell bioelectrical activity. 

IIT    IIT

Italy
Italy

Scientist-in-charge:
Prof Fabio Benfenati

ITALIAN INSTITUTE OF TECHNOLOGY
Neuroscience and Brain Technology Centre for Nanoscience and Technology

IIT-CNST will develop neuron integrated hybrid solid-liquid organic photo-detector (OPD), which will enable a photosensitive approach avoiding genetic cell manipulation or molecular probe loading. 

IIT–NBT will study in vitro and in vivo the impact of organic diodes on CNS primary neuron physiology,adopting standard imaging immunofluorecence and electrophysiological techniques, i.e. patch-clamp and multi-electrode array recordings.


  UPV-EHU


Spain

Scientist-in-charge:
Prof. David Mecerreyes

UNIVERSITY OF THE BASQUE COUNTRY
Institute for Polymer Materials

UPV-EHU will provide expertise and know-how on synthesis of polymeric organic semiconductors polymers will be provided (UPV-EHU) and combined synergistically with Organic Optoelectronics and Neuroscience units to provide materials that improve device performances in aqueous physiological environments, enable biocompatibility and controlled cell growth and orientation of neural cells.

TUM NANO 

  TUM

Italy
Germany

Scientist-in-charge:
Dr Giuseppe Scarpa

TECHNISCHE UNIVERSITÄT MÜNCHEN
Institute for Nanoelectronics

TUM will develop organic photodetectors for optical read-out of neurons and glial cells loaded with voltage sensitive chromophors or fluorescent ions indicators. 

ICL Imperial College London   ICL

Italy
United Kingdom

Scientist-in-charge:
Dr John de Mello

IMPERIAL COLLEGE LONDON
Department of Chemistry

ICL will focus on OLED based devices for interfacing brain cells designed to photo-stimulate light sensitive genetically modified primary culture (in vitro) or transgenic animals (in vivo). ICL will also provide its know-how on microfluidic devices. 


Private Sector



  ETC

Italy
Italy

Scientist-in-charge:
Dr Gianluca Generali

ETC s.r.l.
R&D Department

ETC will develop and characterize OFET devices needed for stimulation and electrical read-out of neural cells. ETC will also develop OLETs that will be employed for photo-stimulation of light sensitive genetically modified primary culture (in vitro) or transgenic animals (in vivo).

  HISTO

Italy
Spain

Scientist-in-charge:
Dr Javier Diez

CENTRE FOR MOLECULAR BIOLOGY AND NEUROSCIENCE
Dept of Anatomy Lab for Molecular Neuroscience

HISTOCELL will first screen bioelectronic materials by testing cell proliferation, cell differentiation and neurite formation in an in vitro nervous system model consisting of neuronal and glial established cell lines (SH-SY5Y and HOG cells). These cells provide us a ready-to-use cell bank to test the consequences of an oxidative environment and evaluate the adequacy of the designed therapies.

 


Associated Partners

Unibo   UNIBO

Italy
Italy

Scientist-in-charge:
Prof .Stefano Ferroni

University of Bologna
Department of Pharmacy and Biotechnology

UNIBO will study in vitro the effect of organic thin films and planar device substructures (OLET/OFET and OECT) on reactive gliosis and on “functional biocompatibility”. In particular, bioelectrical activity of astroglial cells and DRG neurons will be monitored by means of patch-clamp and calcium imaging. 

 

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